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PTPLA Antibody (N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession B0YJ81
Clone Names 100416089
Peptide ID 100416089
Additional Information
Gene ID 9200
Other Names Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1, 3-hydroxyacyl-CoA dehydratase 1, HACD1, Cementum attachment protein, Protein-tyrosine phosphatase-like member A, PTPLA, HACD1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13486a was selected from the N-term region of PTPLA. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name HACD1 {ECO:0000303|PubMed:15164054, ECO:0000312|HGNC:HGNC:9639}
Function Isoform 1: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
Cellular Location Isoform 1: Endoplasmic reticulum membrane; Multi-pass membrane protein
Tissue Location Isoform 1 is highly expressed in the myocardium, and to a lesser extent in skeletal and smooth muscular tissues including those from stomach, jejunum, and bladder. Also detected in gingival fibroblasts, periodontal ligament cells, osteoblasts and cementoblasts (PubMed:11054553, PubMed:22067203) Isoform 2 is specifically expressed by cementoblasts but also detected in periodontal ligament cells, heart, liver and kidney (at protein level) (PubMed:22067203)
Research Areas
Citations (0)

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The protein encoded by this gene contains a characteristiccatalytic motif of the protein tyrosine phosphatases (PTPs) family.The PTP motif of this protein has the highly conserved arginineresidue replaced by a proline residue; thus it may represent adistinct class of PTPs. Members of the PTP family are known to besignaling molecules that regulate a variety of cellular processes.This gene was preferentially expressed in both adult and fetalheart. A much lower expression level was detected in skeletal andsmooth muscle tissues, and no expression was observed in othertissues. The tissue specific expression in the developing and adultheart suggests a role in regulating cardiac development anddifferentiation.


Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Liang, X., et al. Hum. Mutat. 30(3):463-471(2009)Lamesch, P., et al. Genomics 89(3):307-315(2007)Grupe, A., et al. Am. J. Hum. Genet. 78(1):78-88(2006)

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$ 80.00
Cat# BP13486a
Availability: In Stock
Bulk Size
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