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FOXN4 Antibody (N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q96NZ1
Clone Names 100416110
Peptide ID 100416110
Additional Information
Gene ID 121643
Other Names Forkhead box protein N4, FOXN4
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13490a was selected from the N-term region of FOXN4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name FOXN4
Function Transcription factor essential for neural and some non- neural tissues development, such as retina and lung respectively. Binds to an 11-bp consensus sequence containing the invariant tetranucleotide 5'-ACGC-3'. During development of the central nervous system, is required to specify the amacrine and horizontal cell fates from multipotent retinal progenitors while suppressing the alternative photoreceptor cell fates through activating DLL4- NOTCH signaling. Also acts synergistically with ASCL1/MASH1 to activate DLL4-NOTCH signaling and drive commitment of p2 progenitors to the V2b interneuron fates during spinal cord neurogenesis. In development of non-neural tissues, plays an essential role in the specification of the atrioventricular canal and is indirectly required for patterning the distal airway during lung development (By similarity).
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00089}
Research Areas
Citations (0)

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Members of the winged-helix/forkhead family oftranscription factors, such as FOXN4, are characterized by a110-amino acid DNA-binding domain that can fold into a variant ofthe helix-turn-helix motif consisting of 3 alpha helices flanked by2 large loops or wings. These transcription factors are involved ina variety of biologic processes as key regulators in developmentand metabolism (Li et al., 2004 [PubMed 15363391]).[supplied byOMIM].


Scherer, S.E., et al. Nature 440(7082):346-351(2006)Katoh, M., et al. Int. J. Mol. Med. 14(5):949-953(2004)Danilova, N., et al. Brain Res. Dev. Brain Res. 153(1):115-119(2004)Li, S., et al. Neuron 43(6):795-807(2004)

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$ 99.00
Cat# BP13490a
Availability: In Stock
Bulk Size
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