|Other Names||Crk-like protein, CRKL|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13545a was selected from the N-term region of CRKL. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May mediate the transduction of intracellular signals.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein kinase containing SH2 and SH3(src homology) domains which has been shown to activate the RAS andJUN kinase signaling pathways and transform fibroblasts in aRAS-dependent fashion. It is a substrate of the BCR-ABL tyrosinekinase, plays a role in fibroblast transformation by BCR-ABL, andmay be oncogenic.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Kim, Y.H., et al. Oncogene 29(10):1421-1430(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Segovis, C.M., et al. J. Immunol. 182(11):6933-6942(2009)Seo, J.H., et al. Mol. Cell. Biol. 29(11):3076-3087(2009)
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