|Other Names||Tenascin-N, TN-N, TNN|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13618c was selected from the Center region of TNN. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Extracellular matrix protein that seems to be a ligand for ITGA8:ITGB1, ITGAV:ITGB1 and ITGA4:ITGB1 (By similarity) (PubMed:17909022). Involved in neurite outgrowth and cell migration in hippocampal explants (By similarity). During endochondral bone formation, inhibits proliferation and differentiation of proteoblasts mediated by canonical WNT signaling (By similarity). In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (PubMed:19884327). Expressed in most mammary tumors, may facilitate tumorigenesis by supporting the migratory behavior of breast cancer cells (PubMed:17909022).|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
|Tissue Location||Not detected in normal adult mammary tissues or brain but expressed in most breast tumors and brain tumors, such as glioblastomas, astrocytomas and oligodendrogliomas, tested (PubMed:17909022, PubMed:19884327). In brain tumors, detected around the endothelial cell layer of the clood vessels (PubMed:19884327).|
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Provided below are standard protocols that you may find useful for product applications.
TNN is involved in neurite outgrowth and cell migration in hippocampal explants (By similarity).
Gylfe, A.E., et al. Int. J. Cancer (2010) In press :Degen, M., et al. Int. J. Cancer 122(11):2454-2461(2008)Degen, M., et al. Cancer Res. 67(19):9169-9179(2007)Liu, T., et al. J. Proteome Res. 4(6):2070-2080(2005)Scherberich, A., et al. Oncogene 24(9):1525-1532(2005)
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