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HIST2H2AA3 Antibody (N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q6FI13
Clone Names 100427043
Peptide ID 100427043
Additional Information
Gene ID 723790;8337
Other Names Histone H2A type 2-A, Histone H2A2, Histone H2A/o, HIST2H2AA3, H2AFO, HIST2H2AA
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13700a was selected from the N-term region of HIST2H2AA3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms H2AFO, HIST2H2AA
Function Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Cellular Location Nucleus. Chromosome.
Research Areas
Citations (0)

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Histones are basic nuclear proteins that are responsiblefor the nucleosome structure of the chromosomal fiber ineukaryotes. Two molecules of each of the four core histones (H2A,H2B, H3, and H4) form an octamer, around which approximately 146 bpof DNA is wrapped in repeating units, called nucleosomes. Thelinker histone, H1, interacts with linker DNA between nucleosomesand functions in the compaction of chromatin into higher orderstructures. This gene is intronless and encodes a member of thehistone H2A family. Transcripts from this gene lack polyA tails butinstead contain a palindromic termination element. This gene isfound in a histone cluster on chromosome 1. This gene is one offour histone genes in the cluster that are duplicated; this recordrepresents the centromeric copy.


Bergink, S., et al. Genes Dev. 20(10):1343-1352(2006)Bonenfant, D., et al. Mol. Cell Proteomics 5(3):541-552(2006)Boyne, M.T. II, et al. J. Proteome Res. 5(2):248-253(2006)Cao, R., et al. Mol. Cell 20(6):845-854(2005)Hagiwara, T., et al. Biochemistry 44(15):5827-5834(2005)

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$ 80.00
Cat# BP13700a
Availability: In Stock
Bulk Size
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