|Other Names||Eukaryotic translation initiation factor 2A, eIF-2A, 65 kDa eukaryotic translation initiation factor 2A, Eukaryotic translation initiation factor 2A, N-terminally processed, EIF2A|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13720b was selected from the C-term region of EIF2A. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF- 2 complex, it binds methionyl-tRNAi to 40S subunits in a codon- dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.|
|Tissue Location||Widely expressed. Expressed at higher level in pancreas, heart, brain and placenta|
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Provided below are standard protocols that you may find useful for product applications.
EIF2A is a 65-kD protein that catalyzes the formation ofpuromycin-sensitive 80S preinitiation complexes (Zoll et al., 2002[PubMed 12133843]).
Groskreutz, D.J., et al. J. Biol. Chem. 285(31):24023-24031(2010)Bailey, S.D., et al. Diabetes Care (2010) In press :Willis, K.L., et al. Virology 394(1):73-81(2009)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Spurgeon, M.E., et al. J. Virol. 83(19):9970-9982(2009)
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