|Other Names||Chromobox protein homolog 1, HP1Hsbeta, Heterochromatin protein 1 homolog beta, HP1 beta, Heterochromatin protein p25, M31, Modifier 1 protein, p25beta, CBX1, CBX|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13741b was selected from the C-term region of CBX1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane.|
|Cellular Location||Nucleus. Note=Unassociated with chromosomes during mitosis|
|Tissue Location||Expressed in all adult and embryonic tissues.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a highly conserved nonhistone protein,which is a member of the heterochromatin protein family . Theprotein is enriched in the heterochromatin and associated withcentromeres. The protein has a single N-terminal chromodomain whichcan bind to histone proteins via methylated lysine residues, and aC-terminal chromo shadow-domain (CSD) which is responsible for thehomodimerization and interaction with a number ofchromatin-associated nonhistone proteins. The protein may play animportant role in the epigenetic control of chromatin structure andgene expression. Several related pseudogenes are located onchromosomes 1, 3, and X. Multiple alternatively spliced variants,encoding the same protein, have been identified. [provided byRefSeq].
Shiota, M., et al. Endocr. Relat. Cancer 17(2):455-467(2010)Chaturvedi, P., et al. PLoS ONE 5 (5), E10620 (2010) :Souza, P.P., et al. BMC Cell Biol. 10, 41 (2009) :Yahi, H., et al. J. Biol. Chem. 283(35):23692-23700(2008)Olsen, J.V., et al. Cell 127(3):635-648(2006)
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