|Other Names||Nicotinamide N-methyltransferase, NNMT|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13775c was selected from the Center region of NNMT. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is important for biotransformation of many drugs and xenobiotic compounds.|
|Tissue Location||Predominantly expressed in the liver. A lower expression is seen in the kidney, lung, skeletal muscle, placenta and heart. Not detected in the brain or pancreas|
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Provided below are standard protocols that you may find useful for product applications.
N-methylation is one method by which drug and otherxenobiotic compounds are metabolized by the liver. This geneencodes the protein responsible for this enzymatic activity whichuses S-adenosyl methionine as the methyl donor. [provided byRefSeq].
Giusti, B., et al. Thromb. Haemost. 104(2):231-242(2010)Zhang, J., et al. J Zhejiang Univ Sci B 11(2):136-143(2010)Emanuelli, M., et al. Histol. Histopathol. 25(1):15-20(2010)Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :van Driel, L.M., et al. J. Nutr. 139(12):2315-2321(2009)
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