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G3BP1 Antibody (C-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q13283
Clone Names 100430139
Peptide ID 100430139
Additional Information
Gene ID 10146
Other Names Ras GTPase-activating protein-binding protein 1, G3BP-1, ATP-dependent DNA helicase VIII, hDH VIII, GAP SH3 domain-binding protein 1, G3BP1, G3BP
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13785b was selected from the C-term region of G3BP1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name G3BP1
Synonyms G3BP
Function ATP- and magnesium-dependent helicase (PubMed:9889278). Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends (PubMed:9889278). Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency (PubMed:9889278). Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA (PubMed:9889278). Phosphorylation-dependent sequence-specific endoribonuclease in vitro (PubMed:11604510). Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR (PubMed:11604510). May be a regulated effector of stress granule assembly (PubMed:12642610, PubMed:20180778).
Cellular Location Cytoplasm, cytosol. Perikaryon {ECO:0000250|UniProtKB:P97855}. Cytoplasm, Stress granule. Nucleus. Note=Cytoplasmic in proliferating cells (PubMed:11604510). Cytosolic and partially nuclear in resting cells (PubMed:11604510). Recruited to stress granules in response to arsenite treatment (PubMed:12642610, PubMed:20180778) The unphosphorylated form is recruited to stress granules (PubMed:12642610). HRAS signaling contributes to this process by regulating G3BP dephosphorylation (PubMed:12642610)
Tissue Location Ubiquitous.
Research Areas
Citations (0)

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This gene encodes one of the DNA-unwinding enzymes whichprefers partially unwound 3'-tailed substrates and can also unwindpartial RNA/DNA and RNA/RNA duplexes in an ATP-dependent fashion.This enzyme is a member of the heterogeneous nuclear RNA-bindingproteins and is also an element of the Ras signal transductionpathway. It binds specifically to the Ras-GTPase-activating proteinby associating with its SH3 domain. Several alternatively splicedtranscript variants of this gene have been described, but thefull-length nature of some of these variants has not beendetermined.


Gao, X., et al. FEBS Lett. 584(16):3525-3532(2010)Ortega, A.D., et al. J. Cell. Sci. 123 (PT 16), 2685-2696 (2010) :Hinton, S.D., et al. Biochem. J. 427(3):349-357(2010)Shim, J.H., et al. Cancer Prev Res (Phila) 3(5):670-679(2010)Zhang, H.Z., et al. World J. Gastroenterol. 13(30):4126-4130(2007)

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$ 80.00
Cat# BP13785b
Availability: In Stock
Bulk Size
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