|Other Names||Lymphocyte antigen 6E, Ly-6E, Retinoic acid-induced gene E protein, RIG-E, Stem cell antigen 2, SCA-2, Thymic shared antigen 1, TSA-1, LY6E, RIGE, SCA2, TSA1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13818c was selected from the Center region of LY6E. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||9804, RIGE, SCA2, TSA1|
|Function||Involved in T-cell development. Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-3:beta-4-containing nAChRs maximum response.|
|Cellular Location||Cell membrane; Lipid-anchor, GPI-anchor|
|Tissue Location||Widely expressed, predominantly in liver, kidney, ovary, spleen and peripheral blood Leukocytes|
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Provided below are standard protocols that you may find useful for product applications.
Sca1, also known as Ly6A/E, is a member of the Ly6 multigene family of type V glycophosphatidylinositol anchored cell surface proteins. It is expressed on multipotent hematopoietic stem cells in bone marrow of mice with both the Ly6.1 and Ly6.2 allotypes. In the periphery, Sca1 exhibits a pattern of expression which is based on differences between the two allotypes. Ly6.1 strains (e.g., A, BALB/c, CBA, C3H/He, DBA/1, NZB) have few Sca1+ resting peripheral lymphocytes, whereas Ly6.2 strains (e.g., AKR, C57BL, C57BR, C57L, DBA/2, PL, SJL, SWR, 129) have relatively high numbers of Sca1+ lymphocytes. The expression of Sca1 is dramatically upregulated in all strains upon cellular activation.
Davila, S., et al. Genes Immun. 11(3):232-238(2010)Wang, J.L., et al. Mov. Disord. 24(13):2007-2011(2009)Socal, M.P., et al. Parkinsonism Relat. Disord. 15(5):374-378(2009)Tang, J., et al. Lupus 17(9):805-813(2008)Wang, A.G., et al. Biochem. Biophys. Res. Commun. 345(3):1022-1032(2006)
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