|Other Names||Transmembrane and TPR repeat-containing protein 4, TMTC4|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13825a was selected from the N-term region of TMTC4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl-transferases dedicated primarily to the cadherin superfamily, each member seems to have a distinct role in decorating the cadherin domains with O-linked mannose glycans at specific regions. Also acts as O-mannosyl-transferase on other proteins such as PDIA3.|
|Cellular Location||Membrane; Multi-pass membrane protein. Endoplasmic reticulum|
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Provided below are standard protocols that you may find useful for product applications.
TMTC4 belongs to the TMTC family. Its exact function remains unknown.
Tao, W.A., et al. Nat. Methods 2(8):591-598(2005)Rual, J.F., et al. Genome Res. 14 (10B), 2128-2135 (2004) :Dunham, A., et al. Nature 428(6982):522-528(2004)Christian, S.L., et al. Genomics 79(5):635-656(2002)
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