|Other Names||Caspase-6, CASP-6, Apoptotic protease Mch-2, Caspase-6 subunit p18, Caspase-6 subunit p11, CASP6, MCH2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13835a was selected from the N-term region of CASP6. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein which is a member of thecysteine-aspartic acid protease (caspase) family. Sequentialactivation of caspases plays a central role in the execution-phaseof cell apoptosis. Caspases exist as inactive proenzymes whichundergo proteolytic processing at conserved aspartic residues toproduce two subunits, large and small, that dimerize to form theactive enzyme. This protein is processed by caspases 7, 8 and 10,and is thought to function as a downstream enzyme in the caspaseactivation cascade. Alternative splicing of this gene results intwo transcript variants that encode different isoforms. [providedby RefSeq].
Wurstle, M.L., et al. J. Biol. Chem. 285(43):33209-33218(2010)Lee, S.Y., et al. J Thorac Oncol 5(8):1152-1158(2010)Halawani, D., et al. J. Neurosci. 30(17):6132-6142(2010)Kim, M.S., et al. APMIS 118(4):308-312(2010)Yoo, N.J., et al. Tumori 96(1):138-142(2010)
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