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PPM1D Antibody (Center) Blocking peptide

Synthetic peptide

Product Information
Primary Accession O15297
Clone Names 100430203
Peptide ID 100430203
Additional Information
Gene ID 8493
Other Names Protein phosphatase 1D, Protein phosphatase 2C isoform delta, PP2C-delta, Protein phosphatase magnesium-dependent 1 delta, p53-induced protein phosphatase 1, PPM1D, WIP1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13875c was selected from the Center region of PPM1D. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PPM1D
Synonyms WIP1
Function Involved in the negative regulation of p53 expression (PubMed:23242139). Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins (PubMed:15870257, PubMed:16311512). Mediates MAPK14 dephosphorylation and inactivation (PubMed:21283629). Is also an important regulator of global heterochromatin silencing and critical in maintaining genome integrity (By similarity).
Cellular Location Nucleus. Cytoplasm, cytosol
Tissue Location Expressed in fetal and adult brain. Also detected in fetal liver and skeletal muscle, but not in their adult counterparts.
Research Areas
Citations (0)

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The protein encoded by this gene is a member of the PP2Cfamily of Ser/Thr protein phosphatases. PP2C family members areknown to be negative regulators of cell stress response pathways.The expression of this gene is induced in a p53-dependent manner inresponse to various environmental stresses. While being induced bytumor suppressor protein TP53/p53, this phosphatase negativelyregulates the activity of p38 MAP kinase, MAPK/p38, through whichit reduces the phosphorylation of p53, and in turn suppressesp53-mediated transcription and apoptosis. This phosphatase thusmediates a feedback regulation of p38-p53 signaling thatcontributes to growth inhibition and the suppression of stressinduced apoptosis. This gene is located in a chromosomal regionknown to be amplified in breast cancer. The amplification of thisgene has been detected in both breast cancer cell line and primarybreast tumors, which suggests a role of this gene in cancerdevelopment.


Zhang, X., et al. Cancer Res. 70(18):7176-7186(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Moon, S.H., et al. J. Biol. Chem. 285(17):12935-12947(2010)Macurek, L., et al. Oncogene 29(15):2281-2291(2010)Yang, D.H., et al. Zhonghua Yi Xue Za Zhi 90(8):519-522(2010)

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$ 80.00
Cat# BP13875c
Availability: In Stock
Bulk Size
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