|Other Names||Killer cell immunoglobulin-like receptor 2DS1, CD158 antigen-like family member H, MHC class I NK cell receptor Eb6 ActI, CD158h, KIR2DS1, CD158H|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13902c was selected from the Center region of KIR2DS1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Receptor on natural killer (NK) cells for some HLA-C alleles such as w6. Does not inhibit the activity of NK cells.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein; Extracellular side|
|Tissue Location||Expressed by NK cells.|
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Provided below are standard protocols that you may find useful for product applications.
Killer cell immunoglobulin-like receptors (KIRs) aretransmembrane glycoproteins expressed by natural killer cells andsubsets of T cells. The KIR genes are polymorphic and highlyhomologous and they are found in a cluster on chromosome 19q13.4within the 1 Mb leukocyte receptor complex (LRC). The gene contentof the KIR gene cluster varies among haplotypes, although several'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1,KIR3DL4, KIR3DL2). The KIR proteins are classified by the number ofextracellular immunoglobulin domains (2D or 3D) and by whether theyhave a long (L) or short (S) cytoplasmic domain. KIR proteins withthe long cytoplasmic domain transduce inhibitory signals uponligand binding via an immune tyrosine-based inhibitory motif(ITIM), while KIR proteins with the short cytoplasmic domain lackthe ITIM motif and instead associate with the TYRO protein tyrosinekinase binding protein to transduce activating signals. The ligandsfor several KIR proteins are subsets of HLA class I molecules;thus, KIR proteins are thought to play an important role inregulation of the immune response.
Wauquier, N., et al. Immunogenetics 62 (11-12), 767-771 (2010) :Jiao, Y.L., et al. J. Clin. Immunol. 30(6):840-844(2010)Zhu, B.F., et al. Hum. Immunol. 71(11):1116-1123(2010)Velickovic, M., et al. Tissue Antigens 76(4):325-330(2010)Gao, X., et al. Clin. Immunol. 137(1):139-146(2010)
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