|Other Names||Myosin-IIIb, Myo3b|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13924a was selected from the N-term region of Mouse Myo3b. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Probable actin-based motor with a protein kinase activity (By similarity). Required for normal cochlear hair bundle development and hearing. Plays an important role in the early steps of cochlear hair bundle morphogenesis. Influences the number and lengths of stereocilia to be produced and limits the growth of microvilli within the forming auditory hair bundles thereby contributing to the architecture of the hair bundle, including its staircase pattern (PubMed:26754646). Involved in the elongation of actin in stereocilia tips by transporting the actin regulatory factor ESPN to the plus ends of actin filaments (PubMed:22264607).|
|Cellular Location||Cytoplasm, cytoskeleton. Cell projection, stereocilium|
|Tissue Location||Expressed in the cochlear hair cells (at protein level) (PubMed:26754646). Expressed in utricle hair bundles (at protein level) (PubMed:26926603)|
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Provided below are standard protocols that you may find useful for product applications.
Probable actin-based motor with a protein kinase activity (By similarity).
Katti, C., et al. Exp. Eye Res. 89(2):224-237(2009)
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