|Other Names||Methylsterol monooxygenase 1, C-4 methylsterol oxidase, MSMO1, DESP4, ERG25, SC4MOL|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13954b was selected from the C-term region of ERG25. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||DESP4, ERG25, SC4MOL|
|Function||Catalyzes the first step in the removal of the two C-4 methyl groups of 4,4-dimethylzymosterol.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
Sterol-C4-mehtyl oxidase-like protein was isolated basedon its similarity to the yeast ERG25 protein. It contains a set ofputative metal binding motifs with similarity to that seen in afamily of membrane desaturases-hydroxylases. The protein islocalized to the endoplasmic reticulum membrane and is believed tofunction in cholesterol biosynthesis. Alternatively splicedtranscript variants encoding distinct isoforms have been found forthis gene.
Lu, Y., et al. J. Lipid Res. 49(12):2582-2589(2008)Lim, J., et al. Cell 125(4):801-814(2006)Li, L., et al. J. Biol. Chem. 271(28):16927-16933(1996)
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