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HEXIM1 Antibody (N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession O94992
Clone Names 100427223
Peptide ID 100427223
Additional Information
Gene ID 10614
Other Names Protein HEXIM1, Cardiac lineage protein 1, Estrogen down-regulated gene 1 protein, Hexamethylene bis-acetamide-inducible protein 1, Menage a quatre protein 1, HEXIM1, CLP1, EDG1, HIS1, MAQ1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13992a was selected from the N-term region of HEXIM1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms CLP1, EDG1, HIS1, MAQ1
Function Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor (PubMed:14580347, PubMed:15713661, PubMed:15201869). In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:12832472, PubMed:14580347, PubMed:15713661, PubMed:15201869). May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity (PubMed:15940264, PubMed:15941832, PubMed:17088550). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728).
Cellular Location Nucleus Cytoplasm. Note=Binds alpha-importin and is mostly nuclear (PubMed:16362050)
Tissue Location Ubiquitously expressed with higher expression in placenta. HEXIM1 and HEXIM2 are differentially expressed Expressed in endocrine tissues.
Research Areas
Citations (0)

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Expression of this gene is induced byhexamethylene-bis-acetamide in vascular smooth muscle cells. Thisgene has no introns.


Dow, E.C., et al. J. Cell. Physiol. 224(1):84-93(2010)Ogba, N., et al. Oncogene 29(25):3639-3649(2010)Schonichen, A., et al. Biochemistry 49(14):3083-3091(2010)Czudnochowski, N., et al. J. Mol. Biol. 395(1):28-41(2010)Krueger, B.J., et al. PLoS ONE 5 (8), E12335 (2010) :

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$ 80.00
Cat# BP13992a
Availability: In Stock
Bulk Size
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