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PPP2R5C Antibody (C-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q13362
Clone Names 100430300
Peptide ID 100430300
Additional Information
Gene ID 5527
Other Names Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform, PP2A B subunit isoform B'-gamma, PP2A B subunit isoform B56-gamma, PP2A B subunit isoform PR61-gamma, PP2A B subunit isoform R5-gamma, Renal carcinoma antigen NY-REN-29, PPP2R5C, KIAA0044
Target/Specificity The synthetic peptide sequence used to generate the antibody AP14034b was selected from the C-term region of PPP2R5C. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PPP2R5C
Synonyms KIAA0044
Function The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage- induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation.
Cellular Location Nucleus. Chromosome, centromere.
Tissue Location Highest levels in heart, skeletal muscle and brain. Lower levels in pancreas, kidney, lung and placenta. Very low levels in liver
Research Areas
Citations (0)

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The product of this gene belongs to the phosphatase 2Aregulatory subunit B family. Protein phosphatase 2A is one of thefour major Ser/Thr phosphatases, and it is implicated in thenegative control of cell growth and division. It consists of acommon heteromeric core enzyme, which is composed of a catalyticsubunit and a constant regulatory subunit, that associates with avariety of regulatory subunits. The B regulatory subunit mightmodulate substrate selectivity and catalytic activity. This geneencodes a gamma isoform of the regulatory subunit B56 subfamily.Alternatively spliced transcript variants encoding differentisoforms have been identified.


Anney, R., et al. Hum. Mol. Genet. 19(20):4072-4082(2010)Lee, T.Y., et al. J. Biol. Chem. 285(28):21567-21580(2010)Shouse, G.P., et al. Oncogene 29(27):3933-3941(2010)Tung, H.Y., et al. FEBS Lett. 401 (2-3), 197-201 (1997) :McCright, B., et al. J. Biol. Chem. 271(36):22081-22089(1996)

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$ 80.00
Cat# BP14034b
Availability: In Stock
Bulk Size
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