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GLRB Antibody (Center) Blocking peptide

Synthetic peptide

Product Information
Primary Accession P48167
Clone Names 110111041
Peptide ID 110111041
Additional Information
Gene ID 2743
Other Names Glycine receptor subunit beta, Glycine receptor 58 kDa subunit, GLRB
Target/Specificity The synthetic peptide sequence used to generate the antibody AP14080c was selected from the Center region of GLRB. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Function Glycine receptors are ligand-gated chloride channels. GLRB does not form ligand-gated ion channels by itself, but is part of heteromeric ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:8717357, PubMed:15302677, PubMed:16144831, PubMed:22715885, PubMed:25445488, PubMed:11929858, PubMed:23238346). Heteropentameric channels composed of GLRB and GLRA1 are activated by lower glycine levels than homopentameric GLRA1 (PubMed:8717357). Plays an important role in the down-regulation of neuronal excitability (PubMed:11929858, PubMed:23238346). Contributes to the generation of inhibitory postsynaptic currents (PubMed:25445488).
Cellular Location Cell junction, synapse, postsynaptic cell membrane {ECO:0000250|UniProtKB:P48168}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P48167}. Cell junction, synapse {ECO:0000250|UniProtKB:P48168}. Cell projection, dendrite {ECO:0000250|UniProtKB:P48168}. Cell membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:P23415}. Cytoplasm. Note=Retained in the cytoplasm upon heterologous expression by itself. Coexpression with GPHN promotes expression at the cell membrane (PubMed:12684523). Coexpression with GLRA1, GLRA2 or GLRA3 promotes expression at the cell membrane. {ECO:0000250|UniProtKB:P20781, ECO:0000269|PubMed:12684523}
Research Areas
Citations (0)

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This gene encodes the beta subunit of the glycinereceptor, which is a pentamer composed of alpha and beta subunits.The receptor functions as a neurotransmitter-gated ion channel,which produces hyperpolarization via increased chloride conductancedue to the binding of glycine to the receptor. Mutations in thisgene cause startle disease, also known as hereditary hyperekplexiaor congenital stiff-person syndrome, a disease characterized bymuscular rigidity. Alternative splicing results in multipletranscript variants.


Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010)Wheeler, H.E., et al. PLoS Genet. 5 (10), E1000685 (2009) :Ziegler, E., et al. Naunyn Schmiedebergs Arch. Pharmacol. 380(4):277-291(2009)Tabakoff, B., et al. BMC Biol. 7, 70 (2009) :Ahrens, J., et al. Pharmacology 83(4):217-222(2009)

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$ 80.00
Cat# BP14080c
Availability: In Stock
Bulk Size
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