|Other Names||CCAAT/enhancer-binding protein epsilon, C/EBP epsilon, CEBPE|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP14112b was selected from the C-term region of CEBPE. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional activator (PubMed:26019275). C/EBP are DNA-binding proteins that recognize two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. Required for the promyelocyte- myelocyte transition in myeloid differentiation (PubMed:10359588).|
|Tissue Location||Strongest expression occurs in promyelocyte and late-myeloblast-like cell lines.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a bZIP transcriptionfactor which can bind as a homodimer to certain DNA regulatoryregions. It can also form heterodimers with the related proteinCEBP-delta. The encoded protein may be essential for terminaldifferentiation and functional maturation of committed granulocyteprogenitor cells. Mutations in this gene have been associated withSpecific Granule Deficiency, a rare congenital disorder. Multiplevariants of this gene have been described, but the full-lengthnature of only one has been determined.
Prasad, R.B., et al. Blood (2009) In press :Papaemmanuil, E., et al. Nat. Genet. 41(9):1006-1010(2009)Bedi, R., et al. Blood 113(2):317-327(2009)Cloutier, A., et al. J. Immunol. 182(1):563-571(2009)Matsushita, H., et al. Oncogene 27(53):6749-6760(2008)
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