|Other Names||Cadherin-6, Kidney cadherin, K-cadherin, CDH6|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP1415b was selected from the C-term region of human CDH6. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Highly expressed in brain, cerebellum, and kidney. Lung, pancreas, and gastric mucosa show a weak expression Also expressed in certain liver and kidney carcinomas|
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Provided below are standard protocols that you may find useful for product applications.
CDH6 is a type II classical cadherin from the cadherin superfamily. It is a calcium dependent cell-cell adhesion membrane glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Cadherins mediate cell-cell binding in a homophilic manner, contributing to the sorting of heterogeneous cell types and the maintenance of orderly structures such as epithelium. Strong transcriptional expression of the CDH6 gene has been observed in hepatocellular and renal carcinoma cell lines, suggesting a possible role in metastasis and invasion.
Liu,T., J. Proteome Res. 4 (6), 2070-2080 (2005)Shimoyama,Y., Biochem. J. 349 (PT 1), 159-167 (2000)Shimoyama,Y., J. Biol. Chem. 274 (17), 11987-11994 (1999)
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