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CYTH1 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q15438
Clone Names 100430341
Peptide ID 100430341
Additional Information
Gene ID 9267
Other Names Cytohesin-1, PH, SEC7 and coiled-coil domain-containing protein 1, SEC7 homolog B2-1, CYTH1, D17S811E, PSCD1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CYTH1 (HGNC:9501)
Synonyms D17S811E, PSCD1
Function Promotes guanine-nucleotide exchange on ARF1, ARF5 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization, through regulation of ARF6 activity.
Cellular Location Cell membrane; Peripheral membrane protein Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9QX11}. Cell junction, tight junction {ECO:0000250|UniProtKB:Q9QX11}. Cell junction, adherens junction {ECO:0000250|UniProtKB:Q9QX11}. Note=Colocalized with TJP1 during epithelial polarization {ECO:0000250|UniProtKB:Q9QX11}
Tissue Location Ubiquitous.
Research Areas
Citations (0)

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The protein encoded by this gene is a member of the PSCDfamily. Members of this family have identical structuralorganization that consists of an N-terminal coiled-coil motif, acentral Sec7 domain, and a C-terminal pleckstrin homology (PH)domain. The coiled-coil motif is involved in homodimerization, theSec7 domain contains guanine-nucleotide exchange protein (GEP)activity, and the PH domain interacts with phospholipids and isresponsible for association of PSCDs with membranes. Members ofthis family appear to mediate the regulation of protein sorting andmembrane trafficking. This gene is highly expressed in naturalkiller and peripheral T cells, and regulates the adhesiveness ofintegrins at the plasma membrane of lymphocytes. The encodedprotein is 83% homologous to that of CYTH2.


El Azreq, M.A., et al. J. Immunol. 184(2):637-649(2010)Quast, T., et al. Blood 113(23):5801-5810(2009)Sendide, K., et al. J. Immunol. 174(7):4210-4219(2005)Boehm, T., et al. EMBO J. 22(5):1014-1024(2003)Mansour, M., et al. J. Biol. Chem. 277(35):32302-32309(2002)

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$ 80.00
Cat# BP14202a
Availability: In Stock
Bulk Size
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