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FZD5 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q13467
Clone Names 100507018
Peptide ID 100507018
Additional Information
Gene ID 7855
Other Names Frizzled-5, Fz-5, hFz5, FzE5, FZD5, C2orf31
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name FZD5
Synonyms C2orf31
Function Receptor for Wnt proteins (PubMed:9054360, PubMed:10097073, PubMed:20530549). Can activate WNT2, WNT10B, WNT5A, but not WNT2B or WNT4 (in vitro); the in vivo situation may be different since not all of these are known to be coexpressed (By similarity). In neurons, activation of WNT7A promotes formation of synapses (PubMed:20530549). Functions in the canonical Wnt/beta-catenin signaling pathway. The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable). Plays a role in yolk sac angiogenesis and in placental vascularization (By similarity).
Cellular Location Cell membrane {ECO:0000250|UniProtKB:Q8CHL0}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8CHL0}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9EQD0}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9EQD0}. Cell junction, synapse {ECO:0000250|UniProtKB:Q8CHL0}. Perikaryon {ECO:0000250|UniProtKB:Q8CHL0}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q8CHL0}. Cell projection, axon {ECO:0000250|UniProtKB:Q8CHL0}. Note=Localized at the plasma membrane and also found at the Golgi {ECO:0000250|UniProtKB:Q9EQD0}
Research Areas
Citations (0)

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Members of the 'frizzled' gene family encode7-transmembrane domain proteins that are receptors for Wntsignaling proteins. The FZD5 protein is believed to be thereceptor for the Wnt5A ligand.


Moller, M., et al. BMC Infect. Dis. 10, 154 (2010) :Yerges, L.M., et al. J. Bone Miner. Res. 24(12):2039-2049(2009)Terabayashi, T., et al. J. Biol. Chem. 284(39):26716-26724(2009)Kim, J.G., et al. J. Korean Med. Sci. 24(3):443-447(2009)Lin, Z., et al. J. Biol. Chem. 283(48):33053-33058(2008)

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$ 80.00
Cat# BP14210b
Availability: In Stock
Bulk Size
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