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NDUFA13 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9P0J0
Clone Names 100517017
Peptide ID 100517017
Additional Information
Gene ID 51079
Other Names NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13, Cell death regulatory protein GRIM-19, Complex I-B166, CI-B166, Gene associated with retinoic and interferon-induced mortality 19 protein, GRIM-19, Gene associated with retinoic and IFN-induced mortality 19 protein, NADH-ubiquinone oxidoreductase B166 subunit, NDUFA13, GRIM19
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name NDUFA13
Synonyms GRIM19
Function Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis (PubMed:27626371). Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (PubMed:27626371). Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes (PubMed:15753091).
Cellular Location Mitochondrion inner membrane; Single-pass membrane protein; Matrix side. Nucleus Note=Localizes mainly in the mitochondrion (PubMed:12628925). May be translocated into the nucleus upon IFN/RA treatment
Tissue Location Widely expressed, with highest expression in heart, skeletal muscle, liver, kidney and placenta. In intestinal mucosa, down-regulated in areas involved in Crohn disease and ulcerative colitis.
Research Areas
Citations (0)

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This gene encodes a subunit of the mitochondrial membranerespiratory chain NADH dehydrogenase (Complex I), which functionsin the transfer of electrons from NADH to the respiratory chain.The protein is required for complex I assembly and electrontransfer activity. The protein binds the signal transducers andactivators of transcription 3 (STAT3) transcription factor, and canfunction as a tumor suppressor. The human protein purified frommitochondria migrates at approximately 16 kDa. Transcriptsoriginating from an upstream promoter and capable of expressing aprotein with a longer N-terminus have been found, but theirbiological validity has not been determined.


Sun, P., et al. J. Biol. Chem. 285(36):27545-27552(2010)Huang, Y., et al. Exp. Cell Res. 316(13):2061-2070(2010)Zhou, Y., et al. J. Interferon Cytokine Res. 29(10):695-703(2009)Lu, H., et al. Mol. Biol. Cell 19(5):1893-1902(2008)Yeo, W.M., et al. J. Virol. 82(2):1011-1020(2008)

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$ 99.00
Cat# BP14220a
Availability: In Stock
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