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ADD3 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9UEY8
Clone Names 100517093
Peptide ID 100517093
Additional Information
Gene ID 120
Other Names Gamma-adducin, Adducin-like protein 70, ADD3, ADDL
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ADD3
Synonyms ADDL
Function Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Plays a role in actin filament capping (PubMed:23836506). Binds to calmodulin.
Cellular Location Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side
Tissue Location Isoform 1 is ubiquitously expressed.
Research Areas
Citations (0)

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Adducins are heteromeric proteins composed of differentsubunits referred to as adducin alpha, beta and gamma. The threesubunits are encoded by distinct genes and belong to a family ofmembrane skeletal proteins involved in the assembly ofspectrin-actin network in erythrocytes and at sites of cell-cellcontact in epithelial tissues. While adducins alpha and gamma areubiquitously expressed, the expression of adducin beta isrestricted to brain and hematopoietic tissues. Adducin, originallypurified from human erythrocytes, was found to be a heterodimer ofadducins alpha and beta. Polymorphisms resulting in amino acidsubstitutions in these two subunits have been associated with theregulation of blood pressure in an animal model of hypertension.Heterodimers consisting of alpha and gamma subunits have also beendescribed. Structurally, each subunit is comprised of two distinctdomains. The amino-terminal region is protease resistant andglobular in shape, while the carboxy-terminal region is proteasesensitive. The latter contains multiple phosphorylation sites forprotein kinase C, the binding site for calmodulin, and is requiredfor association with spectrin and actin. Alternatively splicedadducin gamma transcripts encoding different isoforms have beendescribed. The functions of the different isoforms are not known.


Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Garcia-Barcelo, M.M., et al. Hum. Mol. Genet. 19(14):2917-2925(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Seidlerova, J., et al. Am. J. Hypertens. 22(1):21-26(2009)

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$ 99.00
Cat# BP14227b
Availability: In Stock
Bulk Size
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