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BIN1 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession O00499
Clone Names 100430092
Peptide ID 100430092
Additional Information
Gene ID 274
Other Names Myc box-dependent-interacting protein 1, Amphiphysin II, Amphiphysin-like protein, Box-dependent myc-interacting protein 1, Bridging integrator 1, BIN1, AMPHL
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name BIN1
Synonyms AMPHL
Function Is a key player in the control of plasma membrane curvature, membrane shaping and membrane remodeling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling (PubMed:24755653). Is a negative regulator of endocytosis (By similarity). Is also involved in the regulation of intracellular vesicles sorting, modulation of BACE1 trafficking and the control of amyloid-beta production (PubMed:27179792). In neuronal circuits, endocytosis regulation may influence the internalization of PHF-tau aggregates (By similarity). May be involved in the regulation of MYC activity and the control cell proliferation (PubMed:8782822). Has actin bundling activity and stabilizes actin filaments against depolymerization in vitro (PubMed:28893863).
Cellular Location Isoform BIN1: Nucleus. Cytoplasm. Endosome {ECO:0000250|UniProtKB:O08539}. Cell membrane, sarcolemma, T- tubule {ECO:0000250|UniProtKB:O08839}
Tissue Location Ubiquitous. Highest expression in the brain and muscle (PubMed:9182667). Expressed in oligodendrocytes (PubMed:27488240). Isoform IIA is expressed only in the brain, where it is detected in the gray matter, but not in the white matter (PubMed:27488240). Isoform BIN1 is widely expressed with highest expression in skeletal muscle
Research Areas
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This gene encodes several isoforms of a nucleocytoplasmicadaptor protein, one of which was initially identified as aMYC-interacting protein with features of a tumor suppressor.Isoforms that are expressed in the central nervous system may beinvolved in synaptic vesicle endocytosis and may interact withdynanim, synaptojanin, endophilin, and clathrin. Isoforms that areexpressed in muscle and ubiquitously expressed isoforms localize tothe cytoplasm and nucleus and activate a caspase-independentapoptotic process. Studies in mouse suggest that this gene plays animportant role in cardiac muscle development. Alternate splicing ofthe gene results in ten transcript variants encoding differentisoforms. Aberrant splice variants expressed in tumor cell lineshave also been described.


Biffi, A., et al. Arch. Neurol. 67(6):677-685(2010)Seshadri, S., et al. JAMA 303(18):1832-1840(2010)Yoshida, T., et al. Int. J. Mol. Med. 25(4):649-656(2010)Claeys, K.G., et al. Neurology 74(6):519-521(2010)Hong, T.T., et al. PLoS Biol. 8 (2), E1000312 (2010) :

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$ 99.00
Cat# BP14348c
Availability: In Stock
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