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ZNF207 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession O43670
Clone Names 100517250
Peptide ID 100517250
Additional Information
Gene ID 7756
Other Names BUB3-interacting and GLEBS motif-containing protein ZNF207, BuGZ, Zinc finger protein 207, ZNF207, BUGZ
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ZNF207 (HGNC:12998)
Function Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly (PubMed:24462186, PubMed:24462187, PubMed:26388440). ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks (PubMed:26388440). Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3 (PubMed:24462186, PubMed:24462187). Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3 (PubMed:24462186). According to another report, the stabilization is independent of the proteasome (PubMed:24462187).
Cellular Location Nucleus. Chromosome, centromere, kinetochore Cytoplasm, cytoskeleton, spindle Note=Localizes primarily to the nucleus in interphase, concentrates at kinetochores prior to nuclear envelope breakdown and during early prometaphase, and disappears from kinetochores upon microtubule-binding.
Tissue Location Ubiquitous..
Research Areas
Citations (0)

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ZNF207 is a new candidate transcription factor.


Andersen, J.S., et al. Nature 433(7021):77-83(2005)Pahl, P.M., et al. Genomics 53(3):410-412(1998)

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$ 80.00
Cat# BP14385a
Availability: In Stock
Bulk Size
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