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SCNM1 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9BWG6
Clone Names 70319123
Peptide ID 70319123
Additional Information
Gene ID 100534012;79005
Other Names Sodium channel modifier 1, SCNM1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP1446c was selected from the Center region of human SCNM1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SCNM1
Function Plays a role in RNA splicing, possibly contributing to the recognition of non-consensus donor sites.
Cellular Location Nucleus. Nucleus speckle. Note=Colocalizes with LUC7L2 and SNRNP70 in nuclear speckles.
Research Areas
Citations (0)

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SCNM1 is a zinc finger protein and putative splicing factor that modifies phenotypic expression of Scn8a mutations in mouse models. Phylogenetic comparison of zinc finger sequences placed SCNM1 within the U1C subfamily of RNA binding proteins that are commonly found in RNA-processing proteins. The SCNM1 protein is localized exclusively to the nucleus. Mutations in the mouse Scn8a gene cause inherited movement disorders that range in severity from tremor to ataxia, dystonia, and juvenile lethality. The severity of the hypomorphic allele Scn8a(medJ) is determined by the unlinked modifier gene Scnm1. The modifier mutation, R187X, is characteristic of strain C57BL/6J and reduces the abundance of correctly spliced sodium channel transcripts below the threshold for survival. Mice with the Scn8a(medJ) mutation on any strain except C57BL/6J have 10% of Scn8a transcript correctly spliced and develop a progressive disorder with dystonia and ataxia but live longer than 1.5 years. The same mutation on a C57BL/6J background results in only 5% of correctly spliced transcript, leading to paralysis and survival less than one month.


Buchner, D.A., et al., Science 301(5635):967-969 (2003).Adams, M.D., et al., Nature 377 (6547 Suppl), 3-174 (1995).

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$ 99.00
Cat# BP1446c
Availability: In Stock
Bulk Size
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