|Other Names||Myc proto-oncogene protein, Class E basic helix-loop-helix protein 39, bHLHe39, Proto-oncogene c-Myc, Transcription factor p64, MYC, BHLHE39|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'- CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis (PubMed:24940000).|
|Cellular Location||Nucleus, nucleoplasm. Nucleus, nucleolus|
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The protein encoded by this gene is a multifunctional,nuclear phosphoprotein that plays a role in cell cycle progression,apoptosis and cellular transformation. It functions as atranscription factor that regulates transcription of specifictarget genes. Mutations, overexpression, rearrangement andtranslocation of this gene have been associated with a variety ofhematopoietic tumors, leukemias and lymphomas, including Burkittlymphoma. There is evidence to show that alternative translationinitiations from an upstream, in-frame non-AUG (CUG) and adownstream AUG start site result in the production of two isoformswith distinct N-termini. The synthesis of non-AUG initiated proteinis suppressed in Burkitt's lymphomas, suggesting its importance inthe normal function of this gene.
Zhang, W., et al. Proc. Natl. Acad. Sci. U.S.A. 107(44):18956-18960(2010)Valera, A., et al. Am. J. Surg. Pathol. 34(11):1686-1694(2010)Goode, E.L., et al. Nat. Genet. 42(10):874-879(2010)Popov, N., et al. Nat. Cell Biol. 12(10):973-981(2010)Amente, S., et al. Cell Cycle 9(15):3002-3004(2010)
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