|Other Names||Nectin-1, Herpes virus entry mediator C, Herpesvirus entry mediator C, HveC, Herpesvirus Ig-like receptor, HIgR, Poliovirus receptor-related protein 1, CD111, PVRL1, HVEC, PRR1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||HVEC, PRR1, PVRL1|
|Function||Promotes cell-cell contacts by forming homophilic or heterophilic trans-dimers. Heterophilic interactions have been detected between NECTIN1 and NECTIN3 and between NECTIN1 and NECTIN4. Has some neurite outgrowth-promoting activity.|
|Cellular Location||Isoform Alpha: Cell membrane; Single-pass type I membrane protein. Cell junction, synapse, presynaptic cell membrane Isoform Gamma: Secreted.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
This gene encodes an adhesion protein that plays a role inthe organization of adherens junctions and tight junctions inepithelial and endothelial cells. The protein is acalcium(2+)-independent cell-cell adhesion molecule that belongs tothe immunoglobulin superfamily and has 3 extracellularimmunoglobulin-like loops, a single transmembrane domain (in someisoforms), and a cytoplasmic region. This protein acts as areceptor for glycoprotein D (gD) of herpes simplex viruses 1 and 2(HSV-1, HSV-2), and pseudorabies virus (PRV) and mediates viralentry into epithelial and neuronal cells. Mutations in this genecause cleft lip and palate/ectodermal dysplasia 1 syndrome (CLPED1)as well as non-syndromic cleft lip with or without cleft palate(CL/P). Alternative splicing results in multiple transcriptvariants encoding proteins with distinct C-termini. [provided byRefSeq].
Nikopensius, T., et al. Birth Defects Res. Part A Clin. Mol. Teratol. 88(9):748-756(2010)Vetter, G., et al. Oncogene 29(31):4436-4448(2010)Kim, J., et al. J. Biol. Chem. 285(30):22919-22926(2010)Jagomagi, T., et al. Eur. J. Oral Sci. 118(3):213-220(2010)Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.