|Other Names||NAD-dependent protein deacetylase sirtuin-3, mitochondrial, hSIRT3, 351-, Regulatory protein SIR2 homolog 3, SIR2-like protein 3, SIRT3, SIR2L3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||NAD-dependent protein deacetylase (PubMed:12186850, PubMed:12374852, PubMed:16788062, PubMed:18680753, PubMed:18794531, PubMed:23283301, PubMed:24121500, PubMed:24252090, PubMed:19535340). Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues (PubMed:12186850, PubMed:12374852, PubMed:16788062, PubMed:18680753, PubMed:18794531, PubMed:23283301, PubMed:24121500, PubMed:24252090). Known targets include ACSS1, IDH, GDH, SOD2, PDHA1, LCAD, SDHA and the ATP synthase subunit ATP5PO (PubMed:16788062, PubMed:18680753, PubMed:24121500, PubMed:24252090, PubMed:19535340). Contributes to the regulation of the cellular energy metabolism (PubMed:24252090). Important for regulating tissue-specific ATP levels (PubMed:18794531). In response to metabolic stress, deacetylates transcription factor FOXO3 and recruits FOXO3 and mitochondrial RNA polymerase POLRMT to mtDNA to promote mtDNA transcription (PubMed:23283301).|
|Cellular Location||Mitochondrion matrix|
|Tissue Location||Widely expressed.|
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This gene encodes a member of the sirtuin family ofproteins, homologs to the yeast Sir2 protein. Members of thesirtuin family are characterized by a sirtuin core domain andgrouped into four classes. The functions of human sirtuins have notyet been determined; however, yeast sirtuin proteins are known toregulate epigenetic gene silencing and suppress recombination ofrDNA. Studies suggest that the human sirtuins may function asintracellular regulatory proteins with mono-ADP-ribosyltransferaseactivity. The protein encoded by this gene is included in class Iof the sirtuin family. Two alternatively spliced transcriptvariants that encode different proteins have been described forthis gene.
Dransfeld, C.L., et al. Int. J. Oncol. 36(4):955-960(2010)Shulga, N., et al. J. Cell. Sci. 123 (PT 6), 894-902 (2010) :Shi, T., et al. J Dig Dis 11(1):55-62(2010)Kong, X., et al. PLoS ONE 5 (7), E11707 (2010) :Li, S., et al. PLoS ONE 5 (5), E10486 (2010) :
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