|Other Names||Synaptosomal-associated protein 23, SNAP-23, Vesicle-membrane fusion protein SNAP-23, SNAP23|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion.|
|Cellular Location||Cell membrane; Peripheral membrane protein. Cell membrane; Lipid-anchor. Cell junction, synapse, synaptosome Note=Mainly localized to the plasma membrane|
|Tissue Location||Ubiquitous. Highest levels where found in placenta|
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Specificity of vesicular transport is regulated, in part,by the interaction of a vesicle-associated membrane protein termedsynaptobrevin/VAMP with a target compartment membrane proteintermed syntaxin. These proteins, together with SNAP25(synaptosome-associated protein of 25 kDa), form a complex whichserves as a binding site for the general membrane fusion machinery.Synaptobrevin/VAMP and syntaxin are believed to be involved invesicular transport in most, if not all cells, while SNAP25 ispresent almost exclusively in the brain, suggesting that aubiquitously expressed homolog of SNAP25 exists to facilitatetransport vesicle/target membrane fusion in other tissues. Theprotein encoded by this gene is structurally and functionallysimilar to SNAP25 and binds tightly to multiple syntaxins andsynaptobrevins/VAMPs. It is an essential component of the highaffinity receptor for the general membrane fusion machinery and isan important regulator of transport vesicle docking and fusion. Twoalternative transcript variants encoding different protein isoformshave been described for this gene.
Greaves, J., et al. J. Biol. Chem. 285(32):24629-24638(2010)Bostrom, P., et al. Diabetes 59(8):1870-1878(2010)Ban, H.J., et al. BMC Genet. 11, 26 (2010) :Kean, M.J., et al. J. Cell. Sci. 122 (PT 22), 4089-4098 (2009) :Gratacos, M., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6), 808-816 (2009) :
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