|Other Names||Follistatin, FS, Activin-binding protein, FST|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH).|
|Tissue Location||Isoform 1 is the predominant isoform in serum but is undetectable in follicular fluid|
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Follistatin is a single-chain gonadal protein thatspecifically inhibits follicle-stimulating hormone release. Thesingle FST gene encodes two isoforms, FST317 and FST344 containing317 and 344 amino acids respectively, resulting from alternativesplicing of the precursor mRNA. In a study in which 37 candidategenes were tested for linkage and association with polycystic ovarysyndrome (PCOS) or hyperandrogenemia in 150 families, evidence wasfound for linkage between PCOS and follistatin. [provided byRefSeq].
Chen, M.J., et al. Hum. Reprod. 25(3):779-785(2010)Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010) :Fajardo, M., et al. Clin. Orthop. Relat. Res. 467(12):3071-3078(2009)Bloise, E., et al. BMC Cancer 9, 320 (2009) :
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