|Other Names||Mitochondrial intermediate peptidase, MIP, MIPEP, MIP|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP1459c was selected from the Center region of human MIPEP. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Cleaves proteins, imported into the mitochondrion, to their mature size.|
|Cellular Location||Mitochondrion matrix.|
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Provided below are standard protocols that you may find useful for product applications.
MIPEP performs the final step in processing a specific class of nuclear-encoded proteins targeted to the mitochondrial matrix or inner membrane. This protein is primarily involved in the maturation of oxidative phosphorylation(OXPHOS)-related proteins. It may contribute to the functional effects of frataxin deficiency and the clinical manifestations of Friedreich ataxia.
Chew A., Genomics 40:493-496(1997).
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