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Mouse Sgk223 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q571I4
Clone Names 110328076
Peptide ID 110328076
Additional Information
Gene ID 244418
Other Names Tyrosine-protein kinase SgK223, Sugen kinase 223, Sgk223, D8Ertd82e
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Prag1 {ECO:0000312|MGI:MGI:1196223}
Function Catalytically inactive protein kinase that acts as a scaffold protein (By similarity). Functions as an effector of the small GTPase RND2, which stimulates RhoA activity and inhibits NGF-induced neurite outgrowth (By similarity). Promotes Src family kinase (SFK) signaling by regulating the subcellular localization of CSK, a negative regulator of these kinases, leading to the regulation of cell morphology and motility by a CSK-dependent mechanism (By similarity). Acts as a critical coactivator of Notch signaling (PubMed:25038227).
Cellular Location Cytoplasm {ECO:0000250|UniProtKB:D3ZMK9}. Nucleus. Cell junction, focal adhesion {ECO:0000250|UniProtKB:Q86YV5}. Note=Colocalized with NOTCH1 in the nucleus (PubMed:25038227)
Research Areas
Citations (0)

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PRAGMIN is also known as SGK223 (sugen kinase 223). The rat homolog was originally identified in a yeast two-hybrid screen for Rnd2 effector proteins expressed in neural cells. Rat Pragmin was found to stimulate RhoA activity for the regulation of neurite outgrowth.


Tanaka, H., et al. J. Biol. Chem. 281(15):10355-10364(2006)

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$ 80.00
Cat# BP14635a
Availability: In Stock
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