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KDELR2 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P33947
Clone Names 100324233
Peptide ID 100324233
Additional Information
Gene ID 11014
Other Names ER lumen protein-retaining receptor 2, ERD2-like protein 1, ELP-1, KDEL endoplasmic reticulum protein retention receptor 2, KDEL receptor 2, KDELR2, ERD22
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms ERD2.2
Function Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi. This receptor recognizes K-D-E-L.
Cellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein
Research Areas
Citations (0)

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Retention of resident soluble proteins in the lumen of theendoplasmic reticulum (ER) is achieved in both yeast and animalcells by their continual retrieval from the cis-Golgi, or apre-Golgi compartment. Sorting of these proteins is dependent on aC-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) inanimal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. Thisprocess is mediated by a receptor that recognizes, and binds thetetrapeptide-containing protein, and returns it to the ER. Inyeast, the sorting receptor encoded by a single gene, ERD2, is aseven-transmembrane protein. Unlike yeast, several human homologsof the ERD2 gene, constituting the KDEL receptor gene family, havebeen described. KDELR2 was the second member of the family to beidentified, and it encodes a protein which is 83% identical to theKDELR1 gene product. Alternative splicing results in multipletranscript variants encoding distinct isoforms. [provided byRefSeq].


van der Vlies, D., et al. Biochem. J. 366 (PT 3), 825-830 (2002) :Pelham, H.R. Cell Struct. Funct. 21(5):413-419(1996)Lewis, M.J., et al. J. Mol. Biol. 226(4):913-916(1992)Hsu, V.W., et al. Cell 69(4):625-635(1992)

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$ 80.00
Cat# BP14724b
Availability: In Stock
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