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ARFGAP1 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q8N6T3
Clone Names 100525056
Peptide ID 100525056
Additional Information
Gene ID 55738
Other Names ADP-ribosylation factor GTPase-activating protein 1, ARF GAP 1, ADP-ribosylation factor 1 GTPase-activating protein, ARF1 GAP, ARF1-directed GTPase-activating protein, ARFGAP1, ARF1GAP
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms ARF1GAP
Function GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated. Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine (By similarity).
Cellular Location Cytoplasm. Golgi apparatus. Note=Associates with the Golgi complex
Research Areas
Citations (0)

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The protein encoded by this gene is a GTPase-activatingprotein (GAP) which associates with the Golgi apparatus and whichinteracts with ADP-ribosylation factor 1 (ARF1). The encodedprotein promotes hydrolysis of ARF1-bound GTP and is required forthe dissociation of coat proteins from Golgi-derived membranes andvesicles. Dissociation of the coat proteins is required for thefusion of these vesicles with target compartments. The activity ofthis protein is stimulated by phosphoinosides and inhibited byphosphatidylcholine. Two transcript variants encoding differentisoforms have been found for this gene.


Saitoh, A., et al. J. Biol. Chem. 284(20):13948-13957(2009)Beck, R., et al. Traffic 10(3):307-315(2009)Weimer, C., et al. J. Cell Biol. 183(4):725-735(2008)Luo, R., et al. J. Biol. Chem. 283(32):21965-21977(2008)Lamesch, P., et al. Genomics 89(3):307-315(2007)

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$ 99.00
Cat# BP14738c
Availability: In Stock
Bulk Size
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