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UBE3A Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q05086
Clone Names 100430196
Peptide ID 100430196
Additional Information
Gene ID 7337
Other Names Ubiquitin-protein ligase E3A, 632-, E6AP ubiquitin-protein ligase, Human papillomavirus E6-associated protein, Oncogenic protein-associated protein E6-AP, Renal carcinoma antigen NY-REN-54, UBE3A, E6AP, EPVE6AP, HPVE6A
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name UBE3A (HGNC:12496)
Function E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates (PubMed:10373495, PubMed:16772533, PubMed:19204938, PubMed:19233847, PubMed:19325566, PubMed:19591933, PubMed:22645313, PubMed:24273172, PubMed:24728990). Several substrates have been identified including the ARNTL/BMAL1, ARC, RAD23A and RAD23B, MCM7 (which is involved in DNA replication), annexin A1, the PML tumor suppressor, and the cell cycle regulator CDKN1B (PubMed:10373495, PubMed:19204938, PubMed:19325566, PubMed:19591933, PubMed:22645313, PubMed:24728990). Additionally, may function as a cellular quality control ubiquitin ligase by helping the degradation of the cytoplasmic misfolded proteins (PubMed:19233847). Finally, UBE3A also promotes its own degradation in vivo. Plays an important role in the regulation of the circadian clock: involved in the ubiquitination of the core clock component ARNTL/BMAL1, leading to its proteasomal degradation (PubMed:24728990). Acts as transcriptional coactivator of progesterone receptor PGR upon progesterone hormone activation (PubMed:16772533). Acts as a regulator of synaptic development by mediating ubiquitination and degradation of ARC (By similarity). Synergizes with WBP2 in enhancing PGR activity (PubMed:16772533).
Cellular Location Cytoplasm {ECO:0000250|UniProtKB:O08759}. Nucleus {ECO:0000250|UniProtKB:O08759}
Research Areas
Citations (0)

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This gene encodes an E3 ubiquitin-protein ligase, part ofthe ubiquitin protein degradation system. This imprinted gene ismaternally expressed in brain and biallelically expressed in othertissues. Maternally inherited deletion of this gene causes AngelmanSyndrome, characterized by severe motor and intellectualretardation, ataxia, hypotonia, epilepsy, absence of speech, andcharacteristic facies. The protein also interacts with the E6protein of human papillomavirus types 16 and 18, resulting inubiquitination and proteolysis of tumor protein p53. Alternativesplicing of this gene results in three transcript variants encodingthree isoforms with different N-termini. Additional transcriptvariants have been described, but their full length nature has notbeen determined.


Peters, S.U., et al. Am. J. Med. Genet. A 152A (8), 1994-2001 (2010) :Wang, H., et al. J. Biol. Chem. 285(17):13201-13210(2010)Zaaroor-Regev, D., et al. Proc. Natl. Acad. Sci. U.S.A. 107(15):6788-6793(2010)Sanduja, S., et al. Aging (Albany NY) 1(9):803-817(2009)Matsuoka, S., et al. Science 316(5828):1160-1166(2007)

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$ 80.00
Cat# BP14799a
Availability: In Stock
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