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TCEB1 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q15369
Clone Names 100525168
Peptide ID 100525168
Additional Information
Gene ID 6921
Other Names Transcription elongation factor B polypeptide 1, Elongin 15 kDa subunit, Elongin-C, EloC, RNA polymerase II transcription factor SIII subunit C, SIII p15, TCEB1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ELOC (HGNC:11617)
Function SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (PubMed:7821821). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells (By similarity).
Cellular Location Nucleus.
Tissue Location Overexpressed in prostate cancer cell line PC- 3 and breast cancer cell line SK-BR-3
Research Areas
Citations (0)

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This gene encodes the protein elongin C, which is asubunit of the transcription factor B (SIII) complex. The SIIIcomplex is composed of elongins A/A2, B and C. It activateselongation by RNA polymerase II by suppressing transient pausing ofthe polymerase at many sites within transcription units. Elongin Afunctions as the transcriptionally active component of the SIIIcomplex, whereas elongins B and C are regulatory subunits. ElonginA2 is specifically expressed in the testis, and capable of forminga stable complex with elongins B and C. The von Hippel-Lindau tumorsuppressor protein binds to elongins B and C, and thereby inhibitstranscription elongation.


Marcsisin, S.R., et al. J. Mol. Biol. 402(5):892-904(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Lievens, S., et al. J. Proteome Res. 8(2):877-886(2009)Jalava, S.E., et al. Int. J. Cancer 124(1):95-102(2009)Piessevaux, J., et al. J. Biol. Chem. 283(31):21334-21346(2008)

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$ 80.00
Cat# BP14814b
Availability: In Stock
Bulk Size
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