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GPC3 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P51654
Clone Names 100507110
Peptide ID 100507110
Additional Information
Gene ID 2719
Other Names Glypican-3, GTR2-2, Intestinal protein OCI-5, MXR7, Secreted glypican-3, GPC3, OCI5
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name GPC3
Synonyms OCI5
Function Cell surface proteoglycan that bears heparan sulfate (PubMed:14610063). Negatively regulates the hedgehog signaling pathway when attached via the GPI-anchor to the cell surface by competing with the hedgehog receptor PTC1 for binding to hedgehog proteins (By similarity). Binding to the hedgehog protein SHH triggers internalization of the complex by endocytosis and its subsequent lysosomal degradation (By similarity). Positively regulates the canonical Wnt signaling pathway by binding to the Wnt receptor Frizzled and stimulating the binding of the Frizzled receptor to Wnt ligands (PubMed:16227623, PubMed:24496449). Positively regulates the non-canonical Wnt signaling pathway (By similarity). Binds to CD81 which decreases the availability of free CD81 for binding to the transcriptional repressor HHEX, resulting in nuclear translocation of HHEX and transcriptional repression (By similarity). Inhibits the dipeptidyl peptidase activity of DPP4 (PubMed:17549790). Plays a role in limb patterning and skeletal development by controlling the cellular response to BMP4 (By similarity). Modulates the effects of growth factors BMP2, BMP7 and FGF7 on renal branching morphogenesis (By similarity). Required for coronary vascular development (By similarity). Plays a role in regulating cell movements during gastrulation (By similarity).
Cellular Location Cell membrane; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:P13265}; Extracellular side {ECO:0000250|UniProtKB:P13265}
Tissue Location Highly expressed in lung, liver and kidney.
Research Areas
Citations (0)

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Background

Cell surface heparan sulfate proteoglycans are composed ofa membrane-associated protein core substituted with a variablenumber of heparan sulfate chains. Members of the glypican-relatedintegral membrane proteoglycan family (GRIPS) contain a coreprotein anchored to the cytoplasmic membrane via a glycosylphosphatidylinositol linkage. These proteins may play a role in thecontrol of cell division and growth regulation. The protein encodedby this gene can bind to and inhibit the dipeptidyl peptidaseactivity of CD26, and it can induce apoptosis in certain celltypes. Deletion mutations in this gene are associated withSimpson-Golabi-Behmel syndrome, also known as Simpson dysmorphiasyndrome. Alternative splicing results in multiple transcriptvariants.

References

Lai, J.P., et al. Hepatology 52(5):1680-1689(2010)Sakurai, M., et al. Gynecol. Oncol. 119(2):332-336(2010)Zynger, D.L., et al. Histopathology 56(6):750-757(2010)Davoodi, J., et al. Proteomics 7(13):2300-2310(2007)Hsu, H.C., et al. Cancer Res. 57(22):5179-5184(1997)

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$ 99.00
Cat# BP14822b
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