|Other Names||Vascular endothelial growth factor B, VEGF-B, VEGF-related factor, VRF, VEGFB, VRF|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis.|
|Cellular Location||Secreted. Note=Secreted but remains associated to cells or to the extracellular matrix unless released by heparin|
|Tissue Location||Expressed in all tissues except liver. Highest levels found in heart, skeletal muscle and pancreas|
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Vascular endothelial growth factor B (VEGFB) signals viathe endothelial receptor VEGFR1 (MIM 165070) and is a regulator ofblood vessel physiology, with a role in endothelial targeting oflipids to peripheral tissues (summarized by Hagberg et al., 2010[PubMed 20228789]).
Iyer, S., et al. J. Biol. Chem. 285(31):23779-23789(2010)Romero, R., et al. Am. J. Obstet. Gynecol. (2010) In press :Bailey, S.D., et al. Diabetes Care (2010) In press :Van Hee, V.C., et al. Environ. Health Perspect. 118(7):962-969(2010)Romero, R., et al. Am. J. Obstet. Gynecol. 202 (5), 431 (2010) :
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