|Other Names||Hyaluronidase-1, Hyal-1, Hyaluronoglucosaminidase-1, Lung carcinoma protein 1, LuCa-1, HYAL1, LUCA1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth.|
|Cellular Location||Secreted. Lysosome|
|Tissue Location||Highly expressed in the liver, kidney and heart. Weakly expressed in lung, placenta and skeletal muscle. No expression detected in adult brain. Isoform 1 is expressed only in bladder and prostate cancer cells, G2/G3 bladder tumor tissues and lymph node specimens showing tumor invasive tumors cells. Isoform 3, isoform 4, isoform 5 and isoform 6 are expressed in normal bladder and bladder tumor tissues.|
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This gene encodes a lysosomal hyaluronidase.Hyaluronidases intracellularly degrade hyaluronan, one of the majorglycosaminoglycans of the extracellular matrix. Hyaluronan isthought to be involved in cell proliferation, migration anddifferentiation. This enzyme is active at an acidic pH and is themajor hyaluronidase in plasma. Mutations in this gene areassociated with mucopolysaccharidosis type IX, or hyaluronidasedeficiency. The gene is one of several related genes in a region ofchromosome 3p21.3 associated with tumor suppression. Multipletranscript variants encoding different isoforms have been found forthis gene.
Lanktree, M.B., et al. Blood 116(12):2160-2163(2010)Gasingirwa, M.C., et al. Biochem. J. 430(2):305-313(2010)Tzuman, Y.C., et al. Neoplasia 12(1):51-60(2010)Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :Wang, X.Y., et al. Chin. Med. J. 122(11):1300-1304(2009)
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