|Other Names||Kinesin-like protein KIF16B, Sorting nexin-23, KIF16B, C20orf23, KIAA1590, SNX23|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP15010a was selected from the KIF16b protein. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||C20orf23, KIAA1590, SNX23|
|Function||Plus end-directed microtubule-dependent motor protein involved in endosome transport and receptor recycling and degradation. Regulates the plus end motility of early endosomes and the balance between recycling and degradation of receptors such as EGF receptor (EGFR) and FGF receptor (FGFR). Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development.|
|Cellular Location||Cytoplasm, cytoskeleton. Early endosome membrane. Note=It is unclear whether association with endosomes is mediated via phosphatidylinositol 3-phosphate (PtdIns(3)P)-binding or via its interaction with RAB14|
|Tissue Location||Primarily expressed in brain. Also present in kidney, liver, intestine, placenta, leukocytes, heart and skeletal muscle (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
KIF16b may be involved in several stages of intracellular trafficking. Probable microtubule-dependent motor protein (By similarity).
Vasilescu, J., et al. J. Proteome Res. 6(1):298-305(2007)Seet, L.F., et al. Biochim. Biophys. Acta 1761(8):878-896(2006)Miki, H., et al. Trends Cell Biol. 15(9):467-476(2005)Hoepfner, S., et al. Cell 121(3):437-450(2005)Worby, C.A., et al. Nat. Rev. Mol. Cell Biol. 3(12):919-931(2002)
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