|Other Names||DCC-interacting protein 13-beta, Dip13-beta, Adapter protein containing PH domain, PTB domain and leucine zipper motif 2, APPL2, DIP13B|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Required for the regulation of cell proliferation in response to extracellular signals mediated by an early endosomal compartment. Links Rab5 to nuclear signal transduction.|
|Cellular Location||Early endosome membrane; Peripheral membrane protein. Nucleus. Note=Early endosomal membrane-bound and nuclear. Translocated into the nucleus upon release from endosomal membranes following internalization of EGF|
|Tissue Location||High levels in brain, heart, kidney and skeletal muscle.|
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Provided below are standard protocols that you may find useful for product applications.
Required for the regulation of cell proliferation in response to extracellular signals mediated by an early endosomal compartment. Links Rab5 to nuclear signal transduction.
Chial, H.J., et al. PLoS ONE 5 (8), E12471 (2010) :Rashid, S., et al. J. Biol. Chem. 284(27):18115-18128(2009)Chial, H.J., et al. Traffic 9(2):215-229(2008)Nechamen, C.A., et al. Mol. Cell. Endocrinol. 260-262, 93-99 (2007) :Mao, X., et al. Nat. Cell Biol. 8(5):516-523(2006)
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