|Other Names||Frizzled-7, Fz-7, hFz7, FzE3, FZD7|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.|
|Cellular Location||Cell membrane; Multi-pass membrane protein Endosome membrane; Multi-pass membrane protein. Note=Associated to the plasma membrane in the presence of FZD7 and phosphatidylinositol 4,5-bisphosphate (PIP2). Localized in recycling endosomes in other conditions|
|Tissue Location||High expression in adult skeletal muscle and fetal kidney, followed by fetal lung, adult heart, brain, and placenta. Specifically expressed in squamous cell esophageal carcinomas|
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Provided below are standard protocols that you may find useful for product applications.
Members of the 'frizzled' gene family encode7-transmembrane domain proteins that are receptors for Wntsignaling proteins. The FZD7 protein contains an N-terminal signalsequence, 10 cysteine residues typical of the cysteine-richextracellular domain of Fz family members, 7 putative transmembranedomains, and an intracellular C-terminal tail with a PDZdomain-binding motif. FZD7 gene expression may downregulate APCfunction and enhance beta-catenin-mediated signals in poorlydifferentiated human esophageal carcinomas.
Guey, L.T., et al. Eur. Urol. 57(2):283-292(2010)Vincan, E., et al. Dev. Dyn. 239(1):311-317(2010)Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :Hosgood, H.D. III, et al. Respir Med 103(12):1866-1870(2009)Ueno, K., et al. Br. J. Cancer 101(8):1374-1381(2009)
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