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NXT1 Blocking Peptide (C-term)

Synthetic peptide

Product Information
Primary Accession Q9UKK6
Other Accession Q9QZV9, Q2KIW0, NP_037380.1
Additional Information
Other Names NTF2-related export protein 1, Protein p15, NXT1
Target/Specificity The synthetic peptide sequence is selected from aa 100-111 of HUMAN NXT1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name NXT1
Function Stimulator of protein export for NES-containing proteins (PubMed:10567585). Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA (PubMed:10848583). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 (PubMed:19165146, PubMed:11259602).
Cellular Location Nucleus. Nucleus speckle. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm EMBL; AF156957; AAD54942.1; -; mRNA EMBL; AL096677; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; BC000759; AAH00759.1; -; mRNA EMBL; BC002687; AAH02687.1; -; mRNA EMBL; BC003029; AAH03029.1; -; mRNA EMBL; BC003410; AAH03410.1; -; mRNA CCDS; CCDS13150.1; - RefSeq; NP_037380.1; NM_013248.2 RefSeq; XP_011527532.1; XM_011529230.2 UniGene; Hs.516933; - PDB; 1JKG; X-ray; 1.90 A; A=1-140 PDB; 1JN5; X-ray; 2.80 A; A=1-140 PDB; 4WYK; X-ray; 3.40 A; B/D=2-140 PDBsum; 1JKG; - PDBsum; 1JN5; - PDBsum; 4WYK; - ProteinModelPortal; Q9UKK6; - SMR; Q9UKK6; - BioGrid; 118875; 12 DIP; DIP-33075N; - IntAct; Q9UKK6; 15 MINT; Q9UKK6; - STRING; 9606.ENSP00000254998; - iPTMnet; Q9UKK6; - PhosphoSitePlus; Q9UKK6; - BioMuta; NXT1; - DMDM; 18203504; - EPD; Q9UKK6; - jPOST; Q9UKK6; - MaxQB; Q9UKK6; - PaxDb; Q9UKK6; - PeptideAtlas; Q9UKK6; - PRIDE; Q9UKK6; - ProteomicsDB; 84812; - TopDownProteomics; Q9UKK6; - Ensembl; ENST00000254998; ENSP00000254998; ENSG00000132661 GeneID; 29107; - KEGG; hsa:29107; - UCSC; uc002wsx.2; human CTD; 29107; - DisGeNET; 29107; - EuPathDB; HostDB:ENSG00000132661.3; - GeneCards; NXT1; - HGNC; HGNC:15913; NXT1 HPA; HPA047471; - MIM; 605811; gene neXtProt; NX_Q9UKK6; - OpenTargets; ENSG00000132661; - PharmGKB; PA31867; - eggNOG; KOG4353; Eukaryota eggNOG; ENOG4111TWR; LUCA GeneTree; ENSGT00940000162041; - HOGENOM; HOG000231890; - HOVERGEN; HBG018207; - InParanoid; Q9UKK6; - KO; K14285; - OMA; YYSTMDK; - OrthoDB; 1450028at2759; - PhylomeDB; Q9UKK6; - TreeFam; TF318944; - Reactome; R-HSA-159236; Transport of Mature mRNA derived from an Intron-Containing Transcript ChiTaRS; NXT1; human EvolutionaryTrace; Q9UKK6; - GeneWiki; NXT1; - GenomeRNAi; 29107; - PRO; PR:Q9UKK6; - Proteomes; UP000005640; Chromosome 20 Bgee; ENSG00000132661; Expressed in 208 organ(s), highest expression level in left coronary artery Genevisible; Q9UKK6; HS GO; GO:0005737; C:cytoplasm; TAS:ProtInc GO; GO:0005829; C:cytosol; IDA:HPA GO; GO:0005643; C:nuclear pore; TAS:ProtInc GO; GO:0044613; C:nuclear pore central transport channel; IBA:GO_Central GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell GO; GO:0005654; C:nucleoplasm; IDA:HPA GO; GO:0008565; F:protein transporter activity; IBA:GO_Central GO; GO:0008536; F:Ran GTPase binding; IEA:Ensembl GO; GO:0006406; P:mRNA export from nucleus; TAS:Reactome GO; GO:0006913; P:nucleocytoplasmic transport; IBA:GO_Central GO; GO:0006606; P:protein import into nucleus; IBA:GO_Central CDD; cd00780; NTF2; 1 InterPro; IPR002075; NTF2 InterPro; IPR032710; NTF2-like_dom_sf InterPro; IPR018222; Nuclear_transport_factor_2_euk Pfam; PF02136; NTF2; 1 SUPFAM; SSF54427; SSF54427; 1 PROSITE; PS50177; NTF2_DOMAIN; 1 1: Evidence at protein level; 3D-structure; Acetylation; Complete proteome; Cytoplasm; Nucleus; Protein transport; Reference proteome; Transport INIT_MET 1 1 Removed. CHAIN 2 140 NTF2-related export protein 1 /FTId=PRO_0000194793 DOMAIN 16 135 NTF2. {ECO:0000255|PROSITE- ProRule:PRU00137} MOD_RES 2 2 N-acetylalanine MUTAGEN 114 114 I->R: 70% reduction in mRNA export activity. MUTAGEN 134 134 R->D: 57% reduction in mRNA export activity and loss of nuclear rim staining. HELIX 6 30 {ECO:0000244|PDB:1JKG} HELIX 32 38 {ECO:0000244|PDB:1JKG} STRAND 39 47 {ECO:0000244|PDB:1JKG} STRAND 50 54 {ECO:0000244|PDB:1JKG} HELIX 55 64 {ECO:0000244|PDB:1JKG} STRAND 68 79 {ECO:0000244|PDB:1JKG} TURN 82 84 {ECO:0000244|PDB:1JKG} STRAND 90 101 {ECO:0000244|PDB:1JKG} STRAND 107 118 {ECO:0000244|PDB:1JKG} STRAND 121 123 {ECO:0000244|PDB:1JKG} STRAND 125 135 {ECO:0000244|PDB:1JKG} TURN 136 139 {ECO:0000244|PDB:1JKG} SEQUENCE 140 AA; 15847 MW; 358FA86AC3944594 CRC64; MASVDFKTYV DQACRAAEEF VNVYYTTMDK RRRLLSRLYM GTATLVWNGN AVSGQESLSE FFEMLPSSEF QISVVDCQPV HDEATPSQTT VLVVICGSVK FEGNKQRDFN QNFILTAQAS PSNTVWKIAS DCFRFQDWAS
Research Areas
Citations (0)

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The protein encoded by this gene is located in the nuclear envelope. It has protein similarity to nuclear transport factor 2. This protein functions as a nuclear export factor in both RAN (Ras-related nuclear protein)- and CRM1 (required for chromosome region maintenance)-dependent pathways. It is found to stimulate the export of U1 snRNA in RAN- and CRM1-dependent pathways and the export of tRNA and mRNA in a CRM1-independent pathway. The encoded protein heterodimerizes with Tap protein and may regulate the ability of Tap protein to mediate nuclear mRNA export. The use of alternate polyadenylation sites has been found for this gene.


Venkatesan, K., et al. Nat. Methods 6(1):83-90(2009)
Forler, D., et al. Nat. Biotechnol. 21(1):89-92(2003)
Katahira, J., et al. J. Biol. Chem. 277(11):9242-9246(2002)
Wiegand, H.L., et al. Mol. Cell. Biol. 22(1):245-256(2002)
Deloukas, P., et al. Nature 414(6866):865-871(2001)

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Cat# BP19752b
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