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FCSD2 Blocking Peptide (C-term)

Synthetic peptide

     
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Product Information
Primary Accession O94868
Other Accession NP_055639.2
Additional Information
Gene ID 9873
Other Names FCH and double SH3 domains protein 2, Carom, SH3 multiple domains protein 3, FCHSD2, KIAA0769, SH3MD3
Target/Specificity The synthetic peptide sequence is selected from aa 721-734 of HUMAN FCHSD2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name FCHSD2
Synonyms KIAA0769, SH3MD3
Function Adapter protein that plays a role in endocytosis via clathrin-coated pits. Contributes to the internalization of cell surface receptors, such as integrin ITGB1 and transferrin receptor (PubMed:29887380). Promotes endocytosis of EGFR in cancer cells, and thereby contributes to the down-regulation of EGFR signaling (PubMed:30249660). Recruited to clathrin-coated pits during a mid- to-late stage of assembly, where it is required for normal progress from U-shaped intermediate stage pits to terminal, omega- shaped pits (PubMed:29887380). Binds to membranes enriched in phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate (PubMed:29887380). When bound to membranes, promotes actin polymerization via its interaction with WAS and/or WASL which leads to the activation of the Arp2/3 complex. Does not promote actin polymerisation in the absence of membranes (PubMed:29887380).
Cellular Location Cytoplasm {ECO:0000250|UniProtKB:Q3USJ8}. Cell junction. Membrane, clathrin- coated pit. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, stereocilium {ECO:0000250|UniProtKB:Q3USJ8}. Note=Partially localized at clathrin-coated pits at the cell membrane (PubMed:30249660) Detected at the cell membrane at sites around clathrin-coated pits, very close to the clathrin-coated pits but not an intrinsic part of the clathrin-coated pits (PubMed:29887380). Colocalizes at cell-cell contacts with CDH1, but is not detected at tight junctions (PubMed:14627983).
Tissue Location Liver, brain, heart, placenta, skeletal muscle, pancreas, lung and kidney.
Research Areas
Citations (0)

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Background

The function of this protein is unknown.

References

Rose, J. Phd, et al. Mol. Med. (2010) In press :
Thalappilly, S., et al. Proteomics 8(15):3071-3081(2008)
Taylor, T.D., et al. Nature 440(7083):497-500(2006)
Katoh, M., et al. Int. J. Mol. Med. 13(5):749-754(2004)
Coyle, I.P., et al. Neuron 41(4):521-534(2004)

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$ 99.00
Cat# BP20110b
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