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(Mouse) Tdgf1 Blocking Peptide (N-term)

Synthetic peptide

Product Information
Primary Accession P51865
Additional Information
Other Names Teratocarcinoma-derived growth factor, Cripto growth factor, Epidermal growth factor-like Cripto protein, Tdgf1, Cripto
Target/Specificity The synthetic peptide sequence is selected from aa 37-50 of HUMAN Tdgf1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Tdgf1
Synonyms Cripto
Function GPI-anchored cell membrane protein involved in Nodal signaling. Cell-associated Tdgf1 acts as a Nodal coreceptor in cis. Shedding of Tdgf1 by Tmem8a modulates Nodal signaling by allowing soluble Tdgf1 to act as a Nodal coreceptor on other cells. Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm.
Cellular Location Cell membrane; Lipid-anchor, GPI-anchor. Secreted {ECO:0000250|UniProtKB:P13385}. Note=Released from the cell membrane by GPI cleavage. {ECO:0000250|UniProtKB:P13385}
Tissue Location Expressed at low level in specific organs of the adult animal such as spleen, heart, lung and brain. During gastrulation, expressed in the forming mesoderm. In later stages of the developing heart, expression is restricted to the truncus arteriosus
Research Areas
Citations (0)

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Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm.


Dono R.,et al.Development 118:1157-1168(1993).
Liguori G.,et al.Mamm. Genome 7:344-348(1996).
Minchiotti G.,et al.Mech. Dev. 90:133-142(2000).
Calvanese L.,et al.J. Med. Chem. 49:7054-7062(2006).

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$ 99.00
Cat# BP21046a
Availability: 2 weeks
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