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LMX1A Blocking Peptide (C-term)

Synthetic peptide

Product Information
Primary Accession Q8TE12
Additional Information
Other Names LIM homeobox transcription factor 1-alpha, LIM/homeobox protein 11, LMX-11, LIM/homeobox protein LMX1A, LMX1A
Target/Specificity The synthetic peptide sequence is selected from aa 303-317 of HUMAN LMX1A
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name LMX1A
Function Acts as a transcriptional activator by binding to an A/T-rich sequence, the FLAT element, in the insulin gene promoter. Required for development of the roof plate and, in turn, for specification of dorsal cell fates in the CNS and developing vertebrae (By similarity).
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00108}
Tissue Location Isoform 1 is expressed in many tissues. Not found in heart, liver, spleen and testis. Relatively highly expressed in fetal brain. Isoform LMX1A-4AB is expressed in testis. EMBL; AY078398; AAL82892.1; -; Genomic_DNA EMBL; AY078391; AAL82892.1; JOINED; Genomic_DNA EMBL; AY078392; AAL82892.1; JOINED; Genomic_DNA EMBL; AY078393; AAL82892.1; JOINED; Genomic_DNA EMBL; AY078394; AAL82892.1; JOINED; Genomic_DNA EMBL; AY078395; AAL82892.1; JOINED; Genomic_DNA EMBL; AY078396; AAL82892.1; JOINED; Genomic_DNA EMBL; AY078397; AAL82892.1; JOINED; Genomic_DNA EMBL; AY078398; AAL82893.1; -; Genomic_DNA EMBL; AY078396; AAL82893.1; JOINED; Genomic_DNA EMBL; AY078397; AAL82893.1; JOINED; Genomic_DNA EMBL; AK127724; BAG54558.1; -; mRNA EMBL; AL160058; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; AL390730; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; CH471067; EAW90744.1; -; Genomic_DNA EMBL; BC119743; AAI19744.1; -; mRNA EMBL; BC119744; AAI19745.1; -; mRNA CCDS; CCDS1247.1; -. [Q8TE12-1] RefSeq; NP_001167540.1; NM_001174069.1. [Q8TE12-1] RefSeq; NP_796372.1; NM_177398.3. [Q8TE12-1] UniGene; Hs.667312; - ProteinModelPortal; Q8TE12; - SMR; Q8TE12; - BioGrid; 110194; 5 IntAct; Q8TE12; 1 STRING; 9606.ENSP00000294816; - iPTMnet; Q8TE12; - PhosphoSitePlus; Q8TE12; - BioMuta; LMX1A; - DMDM; 27923801; - jPOST; Q8TE12; - PaxDb; Q8TE12; - PeptideAtlas; Q8TE12; - PRIDE; Q8TE12; - ProteomicsDB; 74389; - ProteomicsDB; 74390; -. [Q8TE12-2] DNASU; 4009; - Ensembl; ENST00000294816; ENSP00000294816; ENSG00000162761. [Q8TE12-1] Ensembl; ENST00000342310; ENSP00000340226; ENSG00000162761. [Q8TE12-1] Ensembl; ENST00000367893; ENSP00000356868; ENSG00000162761. [Q8TE12-1] GeneID; 4009; - KEGG; hsa:4009; - UCSC; uc001gcz.3; human. [Q8TE12-1] CTD; 4009; - DisGeNET; 4009; - EuPathDB; HostDB:ENSG00000162761.14; - GeneCards; LMX1A; - HGNC; HGNC:6653; LMX1A HPA; HPA028051; - HPA; HPA030088; - MIM; 600298; gene neXtProt; NX_Q8TE12; - OpenTargets; ENSG00000162761; - PharmGKB; PA30416; - eggNOG; KOG0490; Eukaryota eggNOG; ENOG410YIJ3; LUCA GeneTree; ENSGT00940000157774; - HOGENOM; HOG000231629; - HOVERGEN; HBG052335; - InParanoid; Q8TE12; - KO; K09371; - OMA; NDSLWHE; - OrthoDB; 737134at2759; - PhylomeDB; Q8TE12; - TreeFam; TF315442; - SIGNOR; Q8TE12; - ChiTaRS; LMX1A; human GeneWiki; LMX1A; - GenomeRNAi; 4009; - PRO; PR:Q8TE12; - Proteomes; UP000005640; Chromosome 1 Bgee; ENSG00000162761; Expressed in 42 organ(s), highest expression level in pituitary gland Genevisible; Q8TE12; HS GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW GO; GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; ISS:ParkinsonsUK-UCL GO; GO:0007411; P:axon guidance; IEA:Ensembl GO; GO:0021549; P:cerebellum development; IEA:Ensembl GO; GO:0021542; P:dentate gyrus development; IEA:Ensembl GO; GO:0071542; P:dopaminergic neuron differentiation; TAS:ParkinsonsUK-UCL GO; GO:0007626; P:locomotory behavior; IEA:Ensembl GO; GO:0007613; P:memory; IEA:Ensembl GO; GO:1904948; P:midbrain dopaminergic neuron differentiation; ISS:ParkinsonsUK-UCL GO; GO:0045665; P:negative regulation of neuron differentiation; IEA:Ensembl GO; GO:0042048; P:olfactory behavior; IEA:Ensembl GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:ParkinsonsUK-UCL GO; GO:0001558; P:regulation of cell growth; IEA:Ensembl GO; GO:0050808; P:synapse organization; IEA:Ensembl CDD; cd00086; homeodomain; 1 InterPro; IPR009057; Homeobox-like_sf InterPro; IPR017970; Homeobox_CS InterPro; IPR001356; Homeobox_dom InterPro; IPR001781; Znf_LIM Pfam; PF00046; Homeodomain; 1 Pfam; PF00412; LIM; 2 SMART; SM00389; HOX; 1 SMART; SM00132; LIM; 2 SUPFAM; SSF46689; SSF46689; 1 PROSITE; PS00027; HOMEOBOX_1; 1 PROSITE; PS50071; HOMEOBOX_2; 1 PROSITE; PS00478; LIM_DOMAIN_1; 2 PROSITE; PS50023; LIM_DOMAIN_2; 2 1: Evidence at protein level; Activator; Alternative splicing; Complete proteome; Developmental protein; DNA-binding; Homeobox; LIM domain; Metal-binding; Nucleus; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc CHAIN 1 382 LIM homeobox transcription factor 1- alpha /FTId=PRO_0000075825 DOMAIN 33 92 LIM zinc-binding 1. {ECO:0000255|PROSITE- ProRule:PRU00125} DOMAIN 92 154 LIM zinc-binding 2. {ECO:0000255|PROSITE- ProRule:PRU00125} DNA_BIND 195 254 Homeobox. {ECO:0000255|PROSITE- ProRule:PRU00108} COMPBIAS 240 274 Gln-rich COMPBIAS 257 265 Poly-Gln VAR_SEQ 1 249 Missing (in isoform LMX1A-4AB) /FTId=VSP_003112 SEQUENCE 382 AA; 42747 MW; 55424762757FF5FD CRC64; MLDGLKMEEN FQSAIDTSAS FSSLLGRAVS PKSVCEGCQR VILDRFLLRL NDSFWHEQCV QCASCKEPLE TTCFYRDKKL YCKYDYEKLF AVKCGGCFEA IAPNEFVMRA QKSVYHLSCF CCCVCERQLQ KGDEFVLKEG QLLCKGDYEK ERELLSLVSP AASDSGKSDD EESLCKSAHG AGKGTAEEGK DHKRPKRPRT ILTTQQRRAF KASFEVSSKP CRKVRETLAA ETGLSVRVVQ VWFQNQRAKM KKLARRQQQQ QQDQQNTQRL SSAQTNGGGS AGMEGIMNPY TALPTPQQLL AIEQSVYSSD PFRQGLTPPQ MPGDHMHPYG AEPLFHDLDS DDTSLSNLGD CFLATSEAGP LQSRVGNPID HLYSMQNSYF TS
Research Areas
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Acts as a transcriptional activator by binding to an A/T-rich sequence, the FLAT element, in the insulin gene promoter. Required for development of the roof plate and, in turn, for specification of dorsal cell fates in the CNS and developing vertebrae (By similarity).


Thameem F.,et al.Gene 290:217-225(2002).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.

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$ 99.00
Cat# BP21429b
Availability: 2 weeks
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