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SDCG3 Blocking Peptide (N-term)

Synthetic peptide

     
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Product Information
Primary Accession Q96C92
Additional Information
Gene ID 10807
Other Names Serologically defined colon cancer antigen 3, Antigen NY-CO-3, SDCCAG3
Target/Specificity The synthetic peptide sequence is selected from aa 86-99 of HUMAN SDCCAG3
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ENTR1 (HGNC:10667)
Synonyms SDCCAG3
Function Endosome-associated protein that plays a role in membrane receptor sorting, cytokinesis and ciliogenesis (PubMed:23108400, PubMed:25278552, PubMed:27767179). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1 (PubMed:25278552). Involved in the regulation of cytokinesis; the function may involve PTPN13 and GIT1 (PubMed:23108400). Plays a role in the formation of cilia (PubMed:27767179). Involved in cargo protein localization, such as PKD2, at primary cilia (PubMed:27767179). Involved in the presentation of the tumor necrosis factor (TNF) receptor TNFRSF1A on the cell surface, and hence in the modulation of the TNF-induced apoptosis (By similarity).
Cellular Location Cytoplasm {ECO:0000250|UniProtKB:A2AIW0}. Early endosome. Endosome. Recycling endosome. Midbody. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, cilium basal body. Note=Colocalizes in a WASHC2- dependent manner with the retromer CSC complex at endosomes (PubMed:25278552). During cytokinesis colocalized with PTPN13 at the midbody (PubMed:23108400). Colocalizes with IFT88 and gamma- tubulin at the basal body of primary cilia (PubMed:27767179) Colocalizes with IFT88 and pericentrin at the centrosome (PubMed:27767179).
Tissue Location Expressed in the colon (at protein level).
Research Areas
Citations (0)

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Background

SDCG3 may be involved in modulation of TNF response. SDCG3 may be involved in presentation of TNFRSF1A on the cell surface.

References

Olsen, J.V., et al. Cell 127(3):635-648(2006)
Neznanov, N., et al. DNA Cell Biol. 24(12):777-785(2005)

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$ 99.00
Cat# BP4823a
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